Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Emma Pietsch Clear advanced filters

  • The high expression of the DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) often confers resistance to chemotherapy in several cancers. In this study, the authors propose the inhibition of the Wnt signalling pathway as an alternative strategy to modulate MGMT expression and sensitize tumours to chemotherapy.

    • Malin Wickström
    • Cecilia Dyberg
    • John Inge Johnsen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. Thirty-two new loci are found to be associated with BMD, and 6 loci confer higher risk for low-trauma bone fracture.

    • Karol Estrada
    • Unnur Styrkarsdottir
    • Fernando Rivadeneira
    Research
    Nature Genetics
    Volume: 44, P: 491-501

  • Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al. show that Plasmodium does not adhere to a single microtubule structure. Instead, the cytoskeleton changes substantially to produce a unique, fit for purpose structure and organisation at each stage of its life cycle.

    • Josie L. Ferreira
    • Vojtěch Pražák
    • Kay Grünewald
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Noisy gene expression can cause stochasticity in the expression of plant traits. Here, Araújo et al. use a dual reporter system of protein expression in Arabidopsis to show that expression noise is lowest in stomata relative to other tissues and that leaf cells are coupled with respect to noise.

    • Ilka Schultheiß Araújo
    • Jessica Magdalena Pietsch
    • Martin Hülskamp
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Focusing on two ill-characterized subtypes of medulloblastoma (group 3 and group 4), this study identifies prevalent genomic structural variants that are restricted to these two subtypes and independently bring together coding regions of GFI1 family proto-oncogenes with active enhancer elements, leading to their mutually exclusive oncogenic activation.

    • Paul A. Northcott
    • Catherine Lee
    • Stefan M. Pfister
    Research
    Nature
    Volume: 511, P: 428-434