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Showing 1–7 of 7 results
Advanced filters: Author: Emma V. Petley Clear advanced filters

  • Immunoselection underpins tumor antigenic variability and is a key impediment to adoptive cell therapies. Darcy, Beavis and colleagues use T cells engineered to express the dendritic cell growth factor Flt3L to co-opt the host endogenous adaptive immune response and control experimental tumor models.

    • Junyun Lai
    • Sherly Mardiana
    • Paul A. Beavis
    Research
    Nature Immunology
    Volume: 21, P: 914-926

  • Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.

    • Emma V. Petley
    • Hui-Fern Koay
    • Phillip K. Darcy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Adenosine is an immunosuppressive metabolite known to limit anti-tumor immune responses. Here the authors report the characterization of an adenosine A2A receptor (A2AR) eGFP reporter mouse, providing immunological insights into the biology of A2AR expression in the context of anti-tumor immunity.

    • Kirsten L. Todd
    • Junyun Lai
    • Paul A. Beavis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.

    • Jack D. Chan
    • Christina M. Scheffler
    • Phillip K. Darcy
    ResearchOpen Access
    Nature
    Volume: 629, P: 201-210

  • Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors show that CRISPR/Cas9 mediated deletion of A2AR enhances CAR T cell effector functions without altering memory or persistence properties, improving CAR-T mediated tumor control in pre-clinical models.

    • Lauren Giuffrida
    • Kevin Sek
    • Paul A. Beavis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18