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Advanced filters: Author: Emma-Jayne Proctor Clear advanced filters

  • Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a strategy for reducing misfolded SOD1 accumulation.

    • Christen G. Chisholm
    • Rachael Bartlett
    • Justin J. Yerbury
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16