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Showing 1–4 of 4 results
Advanced filters: Author: Emmanuel Deval Clear advanced filters

  • Opioid analgesic drugs act at opioid receptors to exert analgesic effects, but they also exert adverse side effects. In this study, the authors show that the TREK-1 potassium channel is responsible for mediating the analgesic effects of morphine but not the adverse side effects.

    • Maïly Devilliers
    • Jérôme Busserolles
    • Alain Eschalier
    Research
    Nature Communications
    Volume: 4, P: 1-9

  • The R138Q mutation in the Fragile X Mental Retardation 1 (FMR1) gene has been associated with Fragile X syndrome (FXS). Here, the authors present a Fmr1R138Q Knock-In mouse model and show that R138Q mutation results in impaired long-term potentiation and socio-cognitive performance in these mice.

    • Marta Prieto
    • Alessandra Folci
    • Stéphane Martin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Sumoylation plays key roles in neurotransmission but the mechanisms regulating this post-translational system in neurons remain unclear. Here the authors show that synaptic diffusion of the sole SUMO-conjugating enzyme Ubc9 is regulated by synaptic activity via an mGlu5R-dependent signalling pathway.

    • Céline Loriol
    • Frédéric Cassé
    • Stéphane Martin
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density and maturation.

    • Anouar Khayachi
    • Carole Gwizdek
    • Stéphane Martin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17