IL-18 is a member of the IL-1 family of proinflammatory cytokines. Tsutsumi et al.present a crystal structure of IL-18 bound to the extracellular domains of its heterodimeric receptor, providing insight into how its unusual specificity may be targeted pharmacologically.
- Naotaka Tsutsumi
- Takeshi Kimura
- Zenichiro Kato
