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Showing 1–18 of 18 results
Advanced filters: Author: Eric D. Siggia Clear advanced filters

  • Reports on single cell experiments in budding yeast that analyse the role of molecular noise during the G1 phase of the cell cycle. Variability in the timing of G1 can be attributed to variations in cell size at cell birth, as well as variations of a size-independent 'timer' step. These two steps are modular and together control the timing of the critical Start transition of the G1 phase.

    • Stefano Di Talia
    • Jan M. Skotheim
    • Frederick R. Cross
    Research
    Nature
    Volume: 448, P: 947-951

  • This paper presents a general thermodynamic model that accurately captures the relationship between a gene promoter sequence, including weak, stastically undetectable regulatory sites, and its expression output. The work implies a relatively minor role of chromatin and will facilitate rational genetic design in biotechnology and synthetic biology.

    • Jason Gertz
    • Eric D. Siggia
    • Barak A. Cohen
    Research
    Nature
    Volume: 457, P: 215-218

  • In budding yeast, the Start checkpoint in the G1 cell cycle phase is a point after which cells are irreversibly committed to cell division. Previous work has identified a linear pathway that triggers the Start transition. In contrast, analyses of single cells reveal that Start represents a positive feedback-dependent sharp switch that coordinates the simultaneous transcription of a large group of cell cycle genes and the budding of a daughter cell.

    • Jan M. Skotheim
    • Stefano Di Talia
    • Frederick R. Cross
    Research
    Nature
    Volume: 454, P: 291-296

  • Simunovic et al. use human embryonic stem cells to generate a three-dimensional model of a human pre-gastrulation epiblast and show that anterior–posterior symmetry breaking can be induced by BMP4 and WNT signalling.

    • Mijo Simunovic
    • Jakob J. Metzger
    • Eric D. Siggia
    Research
    Nature Cell Biology
    Volume: 21, P: 900-910

  • An in vitro model to study the early events that direct human embryo development after formation of the blastocyst and implantation in the uterine wall.

    • Alessia Deglincerti
    • Gist F. Croft
    • Ali H. Brivanlou
    Research
    Nature
    Volume: 533, P: 251-254

  • This protocol describes how to differentiate and image human embryonic stem cells on micropatterned colonies to create radially organized domains of the germ layers mimicking embryonic gastrulation in vitro.

    • Alessia Deglincerti
    • Fred Etoc
    • Aryeh Warmflash
    Protocols
    Nature Protocols
    Volume: 11, P: 2223-2232

    • Boris I. Shraiman
    • Eric D. Siggia
    Reviews
    Nature
    Volume: 405, P: 639-646

  • Cells in the embryo are subject to autonomous and external mechanical forces that help steer embryonic tissue patterning. Technical developments, such as in vitro models of early embryos, allow probing of the roles of mechanical forces in animal and human embryonic development.

    • Manon Valet
    • Eric D. Siggia
    • Ali H. Brivanlou
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 169-184

  • Gene expression is regulated by an intricate interplay of many factors at different levels. To understand how the currently observed expression patterns have evolved, we need to understand the evolution of the individual regulators and the complex regulatory networks that they form.

    • Kevin Chen
    • Nikolaus Rajewsky
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 93-103

  • Recent work revealed new insights into the temporal regulation of G1–S cell cycle transcription, during proliferation and in response to activation of the DNA replication checkpoint. This has established the importance of G1–S transcription for both cell cycle progression and the maintenance of genome stability.

    • Cosetta Bertoli
    • Jan M. Skotheim
    • Robertus A. M. de Bruin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 518-528