Grosskopf et al. report the development of a tumor inoculation method using self-assembled alginate hydrogels containing different tumorigenic molecules to reproducibly generate tumors in a subcutaneous murine tumor model. They show the impact of this improved model on the reduction of cohort size and increase in the power of the study design.
- Abigail K. Grosskopf
- Santiago Correa
- Eric A. Appel
