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Showing 1–4 of 4 results
Advanced filters: Author: Eric J. Burks Clear advanced filters

  • Microscopic vascular invasion is an indicator of tumour recurrence in lung adenocarcinoma but is challenging to diagnose. Here, the authors use spatial transcriptomics and bulk RNA-seq to identify gene expression changes associated with vascular invasion that are detectable beyond the invasion site.

    • Dylan Steiner
    • Lila Sultan
    • Marc E. Lenburg
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

    • Eric A. Collisson
    • Joshua D. Campbell
    • Ming-Sound Tsao
    ResearchOpen Access
    Nature
    Volume: 511, P: 543-550

  • This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • Rehan Akbani
    • Greg Eley
    ResearchOpen Access
    Nature
    Volume: 507, P: 315-322