This approach leverages the rapid, bio-orthogonal inverse electron demand Diels–Alder reaction between a radiolabeled tetrazine and a trans-cyclooctene–bearing antibody to enable pretargeted positron emission tomography imaging and endoradiotherapy in a murine model of cancer.
- Samantha M. Sarrett
- Outi Keinänen
- Brian M. Zeglis
