Magdeleine Hung et al. report the comprehensive kinetic and structural basis for the inhibition of HIV-1 Reverse Transcriptase by FTC and 3TC, as well as the drug resistant M184V variant. Structural analysis of HIV-1 RT and inhibitors provide insights into the mechanism of binding and resistance.
- Magdeleine Hung
- E. John Tokarsky
- Eric B. Lansdon
