Lymphomas often contain translocations that link c-myc to the immunoglobulin heavy chain locus (encoded by Igh), but the nature of the elements that activate oncogenes within such translocations is unknown. Transgenic mice with Igh 3' regulatory region (Igh3' RR) sequences fused to c-myc are predisposed to B lymphomas. Here, the oncogenic role of the Igh3' RR is investigated by inactivating it in two distinct mouse models for B-cell lymphoma with Igh–c-myc translocations.
- Monica Gostissa
- Catherine T. Yan
- Frederick W. Alt
