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Showing 1–3 of 3 results
Advanced filters: Author: Eric Rosiek Clear advanced filters

  • Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state in melanoma.

    • Miranda V. Hunter
    • Eshita Joshi
    • Richard M. White
    ResearchOpen Access
    Nature
    Volume: 647, P: 517-527

  • Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 chromatin binding and elevated expression of KMT2A and DOT1L as dependencies for ERG oncogenicity.

    • Weiran Feng
    • Erik Ladewig
    • Charles L. Sawyers
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 2177-2191

  • To kill target cells, cytotoxic T lymphocytes (CTLs) form an immune synapse (IS) to elicit cell death and the IS then dissolves to allow for CTL serial killing. Huse et al. find that IS dissolution occurs concomitantly with cytoskeletal contraction of apoptotic targets and this is both necessary and sufficient for CTL dissociation

    • Elisa E. Sanchez
    • Maria Tello-Lafoz
    • Morgan Huse
    Research
    Nature Immunology
    Volume: 24, P: 1434-1442