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Showing 1–3 of 3 results
Advanced filters: Author: Eric Thervet Clear advanced filters

  • In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

    • Hélène Lazareth
    • Carole Henique
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Zuber and colleagues from Paris describe a case of diabetes that developed after renal transplantation in a young, white, nonobese man. Genetic screening detected a newly described deletion in the gene encoding hepatocyte nuclear factor 1 homeobox B,HNF1B, indicating that mutations in HNF1Bmight account for some 'unexpected' cases of new-onset diabetes after transplantation. Minimization of tacrolimus exposure and withdrawal of steroids markedly reduced the patient's insulin requirement.

    • Julien Zuber
    • Christine Bellanné-Chantelot
    • Danièle Dubois-Laforgue
    Reviews
    Nature Reviews Nephrology
    Volume: 5, P: 480-484

  • Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.

    • Carole Henique
    • Guillaume Bollée
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15