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Showing 1–6 of 6 results
Advanced filters: Author: Eric Theveneau Clear advanced filters

  • Epithelial-to-mesenchymal transition is a fundamental morphogenetic process that is often presented as a linear progression, though this has been challenged by in vivo observations. Here they use computational modeling to assess the impact of variability during EMT and highlight nuclear positioning and cell protrusions as drivers of cell extrusion.

    • Steffen Plunder
    • Cathy Danesin
    • Eric Theveneau
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be converted into directional migration by a biased ECM network.

    • Fernanda Bajanca
    • Nadège Gouignard
    • Eric Theveneau
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • During mouse gastrulation the primitive streak is an area of cell division and epithelial-to-mesenchymal transition, though how mitoses and cell delamination are linked is not clear. Here they show that a faster cell cycle and relaxation of the actomyosin cytoskeleton result in the occurrence of non-apical mitosis, which favors cell delamination.

    • Evangéline Despin-Guitard
    • Viviane S. Rosa
    • Isabelle Migeotte
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Mayor and colleagues observed that placodal cell movements in Xenopus and zebrafish embryos are controlled by their interaction with adjacent neural crest cells. Neural crest cells chemotactically migrated towards placodal cells and, on contact, induced neural crest cells to migrate away, revealing a ‘chase-and-run’ behaviour.

    • Eric Theveneau
    • Benjamin Steventon
    • Roberto Mayor
    Research
    Nature Cell Biology
    Volume: 15, P: 763-772

  • In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.

    • Jing Yang
    • Parker Antin
    • Guojun Sheng
    ReviewsOpen Access
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 341-352