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Showing 51–100 of 108 results

Advanced filters: Author: Eric Zimmerman Clear advanced filters

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Genome-wide association and multitrait analyses for dilated cardiomyopathy (DCM) using 9,365 cases and 946,368 controls provide insights into the mechanisms underlying DCM and myocardial resilience

Sean J. Jurgens
Joel T. Rämö
Connie R. Bezzina
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2636-2645
FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

Tingxiang Yan
Jingjing Liang
Xinglong Wang
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer's disease is associated with tau spreading.

Nicolai Franzmeier
Julia Neitzel
Balebail Ashok Raj
ResearchOpen Access17 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation

Yuan Zhang
Paul V. Taufalele
E. Dale Abel
Amendments and Corrections18 Nov 2020
Nature Metabolism

Volume: 2, P: 1498
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Christopher P. Baines
Robert A. Kaiser
Jeffery D. Molkentin
Research31 Mar 2005
Nature

Volume: 434, P: 658-662
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Permissiveness of American bison to infection with severe acute respiratory syndrome coronavirus-2

Mitchell V. Palmer
Alexandra Buckley
Paola M. Boggiatto
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-11
The Genotype-Tissue Expression (GTEx) project

John Lonsdale
Jeffrey Thomas
Helen F Moore
Comments & OpinionOpen Access29 May 2013
Nature Genetics

Volume: 45, P: 580-585
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Liang-Yu Huang
Chen-Chen Tan
Dariella Fernandez
ResearchOpen Access08 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Altered brain function, structure, and developmental trajectory in children born late preterm

Jane E. Brumbaugh
Amy L. Conrad
Peggy C. Nopoulos
Research11 Apr 2016
Pediatric Research

Volume: 80, P: 197-203
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Xue-Ru Fan
Ye He
Xi-Nian Zuo
ResearchOpen Access05 Aug 2025
Communications Biology

Volume: 8, P: 1-16
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

Although multiple reaction monitoring (MRM) mass spectrometry holds considerable promise for quantifying candidate protein biomarkers in blood, transferability of MRM assays between laboratories has never been shown. Addona et al. assess the reproducibility, dynamic range and limits of detection and quantification of MRM across multiple sites.

Terri A Addona
Susan E Abbatiello
Steven A Carr
Research28 Jun 2009
Nature Biotechnology

Volume: 27, P: 633-641
Multiple Geographical Origins of Environmental Sex Determination enhanced the diversification of Darwin’s Favourite Orchids

Oscar Alejandro Pérez-Escobar
Guillaume Chomicki
Jochen Heinrichs
ResearchOpen Access10 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
CPTAC Assay Portal: a repository of targeted proteomic assays

Jeffrey R Whiteaker
Goran N Halusa
Amanda G Paulovich
Correspondence27 Jun 2014
Nature Methods

Volume: 11, P: 703-704
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

A systematic proteomic investigation of disease mediators secreted by pancreatic stellate cells identifies leukaemia inhibitory factor (LIF) as a key factor that acts on cancer cells, promoting tumour progression and chemoresistance.

Yu Shi
Weina Gao
Tony Hunter
Research17 Apr 2019
Nature

Volume: 569, P: 131-135
Optical follow-up of the neutron star–black hole mergers S200105ae and S200115j

The optical follow-up and analysis of two neutron star–black hole merger candidates with the Zwicky Transient Facility did not yield viable counterparts. However, state-of-the-art kilonova models constrain the ejecta properties of these mergers.

Shreya Anand
Michael W. Coughlin
Azamat F. Valeev
Research14 Sept 2020
Nature Astronomy

Volume: 5, P: 46-53
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
Identification of Genes Involved in the Rhizobium-Legume Symbiosis by Mu-dI (Kan, lac)-Generated Transcription Fusions

Eric R. Olson
Michael J. Sadowsky
Desh Pal S. Verma
Research01 Feb 1985
Bio/Technology

Volume: 3, P: 143-149
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease

Yanjia Jason Zhang
Athos Bousvaros
Stacy A. Kahn
ResearchOpen Access06 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Moving back to the future of big data-driven research: reflecting on the social in genomics

Melanie Goisauf
Kaya Akyüz
Gillian M. Martin
ResearchOpen Access04 Aug 2020
Humanities and Social Sciences Communications

Volume: 7, P: 1-9
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan
Jingjing Liang
Xinglong Wang
Amendments and CorrectionsOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-2
Analysis of false-negative rapid diagnostic tests for symptomatic malaria in the Democratic Republic of the Congo

Jonathan B. Parr
Eddy Kieto
Albert Kalonji
ResearchOpen Access22 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
Expanded carrier screening in an infertile population: how often is clinical decision making affected?

Jason M. Franasiak
Meir Olcha
Richard T. Scott Jr
Research03 Mar 2016
Genetics in Medicine

Volume: 18, P: 1097-1101
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Nimodipine improves cortical efficiency during working memory in healthy subjects

Caroline F. Zink
Mellissa Giegerich
Kristin L. Bigos
ResearchOpen Access02 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-8
Variants in DOCK3 cause developmental delay and hypotonia

Kimberly Wiltrout
Alejandro Ferrer
Marwan Shinawi
Research11 Apr 2019
European Journal of Human Genetics

Volume: 27, P: 1225-1234
Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5

Eric D. Young
Sharon J. Manley
Danny R. Welch
ResearchOpen Access07 Oct 2020
British Journal of Cancer

Volume: 124, P: 166-175
Erratum: Abnormal Stress Responsivity in a Rodent Developmental Disruption Model of Schizophrenia

Eric C Zimmerman
Mark Bellaire
Anthony A Grace
Amendments and Corrections09 Jan 2015
Neuropsychopharmacology

Volume: 40, P: 791
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian
Yousef Jamali
Ansgar J. Furst
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-17
Bovine NK-lysin peptides exert potent antimicrobial activity against multidrug-resistant Salmonella outbreak isolates

Rohana P. Dassanayake
Briony M. Atkinson
Shawn M. D. Bearson
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-17
Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Takaki Oka
Yuki Matsuzawa
Balebail Ashok Raj
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy

Yetrib Hathout
Chen Liang
Craig McDonald
ResearchOpen Access21 Aug 2019
Scientific Reports

Volume: 9, P: 1-13
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Suprateek Kundu
Joshua Lukemire
Ansgar J. Furst
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-18
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children

Yetrib Hathout
Laurie S. Conklin
Eric P. Hoffman
ResearchOpen Access17 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
NAFLD in Asia—as common and important as in the West

NAFLD prevalence in most regions of Asia is increasing. This Review presents emerging data on genetic polymorphisms that predispose Asian people to NAFLD, NASH and cirrhosis, and discusses the clinical and pathological outcomes of these diseases.

Geoffrey C. Farrell
Vincent Wai-Sun Wong
Shiv Chitturi
Reviews05 Mar 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 307-318
The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Jeroen W. G. Derksen
Geraldine R. Vink
David D. E. Zimmerman
ResearchOpen Access16 Feb 2021
Scientific Reports

Volume: 11, P: 1-12
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Yeonwoo Chung
Hyunju Lee
Kristin Fargher
ResearchOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment

Masataka Wada
Yoshihiro Noda
Shinichiro Nakajima
Reviews20 Apr 2022
Molecular Psychiatry

Volume: 27, P: 2950-2967
Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Sheng-Yao Huang
Jung-Lung Hsu
Balebail Ashok Raj
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
ResearchOpen Access25 Sept 2019
Scientific Reports

Volume: 9, P: 1-16
Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Margherita Squillario
Giulia Abate
Kristin Fargher
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

Yogatheesan Varatharajah
Vijay K. Ramanan
Kristin Fargher
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Xinpeng Shen
Sisi Ma
Kristin Fargher
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-12

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