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Showing 1–7 of 7 results
Advanced filters: Author: Erica C. Pehrsson Clear advanced filters

  • Although most are silenced, certain transposable elements (TEs) have been co-opted by the host. Here, the authors quantify the epigenomic status of TEs using data from the Roadmap Epigenomics Project, provide a systematic profile of TE activity across normal human tissues and development, finding that TEs encompass a quarter of the human regulatory epigenome, with 47% of TEs in regulatory states.

    • Erica C. Pehrsson
    • Mayank N. K. Choudhary
    • Ting Wang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • An analysis of bacterial community structure and antibiotic resistance gene content of interconnected human faecal and environmental samples from two low-income communities in Latin America was carried out using a combination of functional metagenomics, 16S sequencing and shotgun sequencing; resistomes across habitats are generally structured along ecological gradients, but key resistance genes can cross these boundaries, and the authors assessed the usefulness of excreta management protocols in the prevention of resistance gene dissemination.

    • Erica C. Pehrsson
    • Pablo Tsukayama
    • Gautam Dantas
    Research
    Nature
    Volume: 533, P: 212-216

  • The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as cis-regulatory modules in synergistic fashion.

    • Vasavi Sundaram
    • Mayank N. K. Choudhary
    • Ting Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Genomic, transcriptomic and DNA methylation data from tissue samples from 208 Chinese patients with prostate cancer define the landscape of alterations in this population, and comparison with data from Western cohorts suggests that the disease may stratify into different molecular subtypes.

    • Jing Li
    • Chuanliang Xu
    • Yinghao Sun
    Research
    Nature
    Volume: 580, P: 93-99