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Showing 1–4 of 4 results
Advanced filters: Author: Erica M Duguid Clear advanced filters

  • Base lesions can be directly repaired by oxidative dealkylation catalysed by AlkB in bacteria and by ABH2/ABH3 in man. Several structures of AlkB and ABH2 bound to dsDNA are solved. These structures reveal why AlkB prefers ssDNA to dsDNA substrates, and how ABH2 differs structurally, to allow it to repair dsDNA.

    • Cai-Guang Yang
    • Chengqi Yi
    • Chuan He
    Research
    Nature
    Volume: 452, P: 961-965

  • Allosteric effectors have the ability to modulate protein-ligand interactions in a controlled fashion. Now a novel class of antibody-like affinity reagents, synthetic antigen binders or sABs, are generated in vitro that target either the open or closed form of maltose-binding protein. These sABs can be engineered to control ligand-binding affinities by modulating the transition between different conformations.

    • Shahir S Rizk
    • Marcin Paduch
    • Anthony A Kossiakoff
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 437-442

  • Crystallization of RNA molecules can pose a challenge, and the U1A RNA binding protein has been used to facilitate the process. Now a different portable RNA sequence and a synthetic Fab are presented as tools for RNA structural determination. In addition to functioning as a crystallization chaperone, the Fab also serves as the search model to provide phase information.

    • Yelena Koldobskaya
    • Erica M Duguid
    • Joseph A Piccirilli
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 100-106