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Showing 1–4 of 4 results
Advanced filters: Author: Erica Squire Clear advanced filters

  • Circulating monocytes contribute to the transition to pain chronicity but the molecular events that cause their deployment are still unclear. Using a mouse model of hyperalgesic priming, here the authors show that blood monocytes contribute to the emergence of chronic pain via a mechanism that requires a transient disruption of NAAA-regulated lipid signaling.

    • Yannick Fotio
    • Alex Mabou Tagne
    • Daniele Piomelli
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • X-ray crystal structures of TokK, a cobalamin- or B12-dependent radical SAM methylase, provide insight into how these enzymes use sequential radical-mediated methylations to assemble the C6 side chain of carbapenem antibiotics.

    • Hayley L. Knox
    • Erica K. Sinner
    • Squire J. Booker
    Research
    Nature
    Volume: 602, P: 343-348

  • Crystal structures of a cobalamin-dependent radical S-adenosylmethionine (SAM) methylase reveal an unexpected mechanism that involves substrate-assisted catalysis whereby the carboxylate group of the co-substrate SAM serves as a general base.

    • Hayley L. Knox
    • Percival Yang-Ting Chen
    • Squire J. Booker
    Research
    Nature Chemical Biology
    Volume: 17, P: 485-491

  • The radical SAM enzyme Cfr catalyzes methylation of a ribosomal adenosine, causing broad antibiotic resistance. EPR and ENDOR techniques now provide direct evidence for the proposed enzymatic mechanism by detecting a central crosslinked intermediate in which a radical is located on the nucleotide.

    • Tyler L Grove
    • Jovan Livada
    • Alexey Silakov
    Research
    Nature Chemical Biology
    Volume: 9, P: 422-427