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Communications Biology (1)

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Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity

Single-cell RNA sequencing shows neonatal morphine alters adolescent midbrain gene expression, downregulating HOX genes and affecting pain/neurotransmitter pathways, an effect mitigated by probiotic (B.infantis) supplementation.

Junyi Tao
Danielle Antoine
Sabita Roy
ResearchOpen Access10 Dec 2025
Communications Biology

Volume: 8, P: 1-15

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Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity

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