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Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia

Autry et al. combine genome-wide genomic, epigenetic and transcriptomic analyses in an integrated polygenomic approach to identify mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia.

Robert J. Autry
Steven W. Paugh
William E. Evans
Research09 Mar 2020
Nature Cancer

Volume: 1, P: 329-344
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

William Evans and colleagues find that the proinflammatory genes CASP1 and NLRP3 are expressed at higher levels in primary acute lymphoblastic leukemia cells that are resistant than in those that are sensitive to glucocorticoid treatment. They find that CASP1 mediates glucocorticoid resistance through cleavage of the glucocorticoid receptor.

Steven W Paugh
Erik J Bonten
William E Evans
Research04 May 2015
Nature Genetics

Volume: 47, P: 607-614
Biophysical and functional study of CRL5^Ozz, a muscle specific ubiquitin ligase complex

Yvan Campos
Amanda Nourse
Alessandra d’Azzo
ResearchOpen Access12 May 2022
Scientific Reports

Volume: 12, P: 1-15

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