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Showing 1–4 of 4 results
Advanced filters: Author: Erik McShane Clear advanced filters

  • The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins on the disassembly of the p97 complex.

    • Anup Arumughan
    • Yvette Roske
    • Erich E. Wanker
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.

    • Rebecca L. Eccles
    • Maciej T. Czajkowski
    • Oliver Rocks
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their cell bodies and neurites, providing a unique resource for future studies on neuronal polarity.

    • Alessandra Zappulo
    • David van den Bruck
    • Marina Chekulaeva
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13