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Showing 1–3 of 3 results
Advanced filters: Author: Eriko Sakakura Clear advanced filters

  • Organoid technology has been applied to model many types of organs in vitro, although structures containing multiple germ layers, such as limb buds, have not been generated. Here, the authors induce limb bud-like tissues from mouse ESCs that can be functionally integrated after transplantation.

    • Shunsuke Mori
    • Eriko Sakakura
    • Mototsugu Eiraku
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Organogenesis relies on the orchestration of many cellular interactions to create the collective cell behaviours that progressively shape developing tissues. Using a three-dimensional embryonic stem cell culture system, this study successfully generated neural retinal tissues that formed a fully stratified neural retinal structure with all the major components located in their proper spatial location as seen during optic-cup development in vivo. This approach might have important implications for stem cell therapy for retinal repair.

    • Mototsugu Eiraku
    • Nozomu Takata
    • Yoshiki Sasai
    Research
    Nature
    Volume: 472, P: 51-56

  • The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential activation of localised Fgf then Wnt signalling.

    • Nozomu Takata
    • Eriko Sakakura
    • Yoshiki Sasai
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16