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Nature Communications (2)
Neuropsychopharmacology (1)

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Showing 1–3 of 3 results

Advanced filters: Author: Erin N. Lessie Clear advanced filters

Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels

Voltage sensors in hERG potassium channels regulate heartbeat, and their mutations can cause arrhythmias. Here, authors combine fluorescence lifetime imaging and computational modeling to reveal impaired sensor movements in disease, uncovering a detailed structural mechanism.

Aaron N. Chan
Co D. Quach
Gucan Dai
ResearchOpen Access03 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons

Nanoscale membrane lipid domains are emerging as important regulators of ion channel function. This study highlights their role in modulating pacemaker HCN channels in sensory neurons, revealing a mechanism that may contribute to neuropathic pain.

Lucas J. Handlin
Natalie L. Macchi
Gucan Dai
ResearchOpen Access15 Nov 2024
Nature Communications

Volume: 15, P: 1-20
PET clinical study of novel antipsychotic LB-102 demonstrates unexpectedly prolonged dopamine receptor target engagement

Dean F. Wong
Ganesh B. Chand
Andrew R. Vaino
ResearchOpen Access16 Oct 2024
Neuropsychopharmacology

Volume: 50, P: 372-377