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Targeting of intracellular oncoproteins with peptide-centric CARs

Peptide-centric chimeric antigen receptors (PC-CARs) provide a platform to address the challenges involved in targeting intracellular oncoproteins, and PC-CARs based on the neuroblastoma-dependency gene PHOX2B induce elimination of aggressive tumors.

Mark Yarmarkovich
Quinlen F. Marshall
John M. Maris
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 820-827
Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Mark Yarmarkovich
Quinlen F. Marshall
John M. Maris
Amendments and CorrectionsOpen Access08 Nov 2023
Nature

Volume: 623, P: 872
RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Targeting peptides from unmutated cancer drivers that are expressed in tumours but not in normal tissues using peptide-centric chimeric antigen receptors shows potential as treatment for cancer.

Mark Yarmarkovich
Quinlen F. Marshall
John M. Maris
ResearchOpen Access03 Nov 2021
Nature

Volume: 599, P: 477-484

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Targeting of intracellular oncoproteins with peptide-centric CARs

Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

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