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Showing 1–2 of 2 results
Advanced filters: Author: Erin Skeens Clear advanced filters

  • A detailed understanding of the catalytic target DNA cleavage mechanism by CRISPR–Cas9 has been lacking. Now the key modulating role of Mg2+ in the conformational activation of Cas9 and the influence of active site residues on the protonation state of catalytic H840 are demonstrated, ultimately unravelling the catalytic mechanism.

    • Łukasz Nierzwicki
    • Kyle W. East
    • Giulia Palermo
    Research
    Nature Catalysis
    Volume: 5, P: 912-922