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Showing 1–8 of 8 results

Advanced filters: Author: Erkan Karakas Clear advanced filters

Structural basis for DNA recognition and processing by UvrB

James J Truglio
Erkan Karakas
Caroline Kisker
Research12 Mar 2006
Nature Structural & Molecular Biology

Volume: 13, P: 360-364
Structural basis for activation and gating of IP₃ receptors

IP₃ receptors are intracellular calcium channels involved in numerous signaling pathways. Here, the authors present the cryo-EM structures of type-3 IP₃ receptors in multiple gating conformations, including the active state revealing the molecular mechanism of the receptor activation.

Emily A. Schmitz
Hirohide Takahashi
Erkan Karakas
ResearchOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1-9
Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling

Protease containing ABC Transporters (PCAT) play a critical role in the translocation of polypeptides across membranes. Here, authors reveal the structural and energetic of the ATP-powered conformational cycle that enable this process.

Ruojing Zhang
Kevin L. Jagessar
Hassane S. Mchaourab
ResearchOpen Access20 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

Erkan Karakas
Noriko Simorowski
Hiro Furukawa
Research15 Jun 2011
Nature

Volume: 475, P: 249-253
Structural insights into the mechanism of the sodium/iodide symporter

Mutations in the sodium/iodide symporter (NIS) cause congenital hypothyroidism, and our results yield insights into how NIS selects, couples and translocates anions, thereby establishing a framework for understanding NIS function.

Silvia Ravera
Juan Pablo Nicola
Nancy Carrasco
Research14 Dec 2022
Nature

Volume: 612, P: 795-801
Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter

Multidrug resistance through active extrusion of molecules by transporters is a pressing clinical problem. Here, authors dissect the mechanism by which an ABC transporter from B. Subtilis binds and removes drugs by consuming the energy of ATP hydrolysis.

Qingyu Tang
Matt Sinclair
Hassane S. Mchaourab
ResearchOpen Access08 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

X-ray crystallography, single-particle electron cryomicroscopy and electrophysiology were used to study the conformational changes that take place during the activation and inhibition of a mammalian GluN1b–GluN2B N-methyl-d-aspartate receptor.

Nami Tajima
Erkan Karakas
Hiro Furukawa
Research02 May 2016
Nature

Volume: 534, P: 63-68
A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs

Molecular modeling and functional mutagenesis analysis identify a novel mechanism of LRRC8 volume-regulated anion channel inhibition by structurally distinct lipophilic drugs

Toshiki Yamada
Paola Bisignano
Jerod S. Denton
ResearchOpen Access06 Oct 2025
Communications Biology

Volume: 8, P: 1-13