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Induction of neoantigen-reactive T cells from healthy donors

The percentage of cancer neoantigens that are spontaneously recognized by T cells is generally very low. This protocol describes how CD8⁺ T cells from healthy donors can be used for enhanced targeting of these neoantigens.

Muhammad Ali
Zsofia Foldvari
Johanna Olweus
Protocols17 May 2019
Nature Protocols

Volume: 14, P: 1926-1943
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Engineered T cells kill leukemic cells with little off-target toxicity.

Muhammad Ali
Eirini Giannakopoulou
Johanna Olweus
ResearchOpen Access06 Dec 2021
Nature Biotechnology

Volume: 40, P: 488-498

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Induction of neoantigen-reactive T cells from healthy donors

T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

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