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Showing 1–18 of 18 results
Advanced filters: Author: Ernst J. Kuipers Clear advanced filters

  • Endoscopy is the mainstay for diagnosis and therapy of upper gastrointestinal bleeding. Early risk assessment is crucial for effective timing of endoscopy and determination of the need for other measures to be taken—scoring systems should be used for this purpose. A new prospective study suggests that the Blatchford score can identify patients who do not need endoscopic intervention.

    • Ernst J. Kuipers
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 7, P: 480-482

  • In this Perspectives, the authors highlight the bacteria identified as potential pathobionts (that is, pathogenic bacteria) in CRC. Furthermore, possible novel therapeutic avenues for rational prevention of pathogenic inflammation are outlined, as well as potential screening methods for CRC that target the human gut microbiota.

    • Sergey R. Konstantinov
    • Ernst J. Kuipers
    • Maikel P. Peppelenbosch
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 741-745

  • Many methods are available for colorectal cancer (CRC) screening, ranging from noninvasive stool tests to endoscopy. In this Review, E. J. Kuipers et al. argue that the strength of any single test must be viewed in the context of a range of factors across the screening programme, including test characteristics, uptake, screenee autonomy, cost, endoscopy performance and long-term follow-up.

    • Ernst J. Kuipers
    • Thomas Rösch
    • Michael Bretthauer
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 10, P: 130-142

  • Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the physiological esophagus, and may underlie the phenotypic aspects of metaplasia and increase proliferation.

    • Vincent T. Janmaat
    • Kateryna Nesteruk
    • Maikel P. Peppelenbosch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Colorectal cancer (CRC) screening strongly reduces CRC-related mortality, with the effects of screening persisting for 20–30 years. These observations support current CRC screening and surveillance guidelines. At the population level, screening contributes to longer, healthier living. Thus, it is one small step for mankind, yet one giant leap for man.

    • Ernst J. Kuipers
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 11, P: 5-6

  • Colorectal cancer screening can save lives but there is a need for targeted, personalized screening. A new study examines an individual risk assessment based on family history, lifestyle, environmental and genetic factors, but faecal haemoglobin levels and their change over time can also help to further identify patients at high risk.

    • Ernst J. Kuipers
    • Manon C. Spaander
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 15, P: 391-392

  • Colorectal cancer is a common cancer globally; its increased incidence over the past 60 years is associated with red meat consumption, smoking, alcohol intake and an ageing population. Here, Kuipers et al. describe the biology and treatment of colorectal cancers, and discuss the impact that screening will have on outcomes.

    • Ernst J. Kuipers
    • William M. Grady
    • Toshiaki Watanabe
    Reviews
    Nature Reviews Disease Primers
    Volume: 1, P: 1-25

  • After curative treatment, 30% of patients with stage I–III and up to 65% of patients with stage IV colorectal cancer (CRC) develop recurrent disease. Thus, surveillance for disease recurrence is clearly needed in these patients, but controversy surrounds the optimal follow-up approaches. Herein, the current evidence relating to surveillance strategies for patients with CRC is comprehensively reviewed, and the future development of patient-centred programmes is discussed.

    • Eric P. van der Stok
    • Manon C. W. Spaander
    • Ernst J. Kuipers
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 297-315

  • Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

    • Zhan Su
    • Laura J Gay
    • Janusz A Z Jankowski
    Research
    Nature Genetics
    Volume: 44, P: 1131-1136

  • Young-onset colorectal cancer occurs in individuals younger than 50 years and is increasing in incidence worldwide. This Primer provides an overview of the epidemiology, diagnosis, screening, prevention, pathophysiology and management of this cancer and its impact on patient quality of life.

    • Manon C. W. Spaander
    • Ann G. Zauber
    • Ernst J. Kuipers
    Reviews
    Nature Reviews Disease Primers
    Volume: 9, P: 1-21