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Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Yu-Hwa Huang
Chen Zhu
Richard S. Blumberg
Amendments and Corrections09 Feb 2024
Nature

Volume: 626, P: E19
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin

Niemann–Pick disease is characterized by the cellular accumulation of sphingomyelin. Blumberg and colleagues use both mouse models and materials from patients with Niemann–Pick disease to show that sphingomyelin accumulation inhibits CD1d-restricted NKT cell activation and development.

Espen Melum
Xiaojun Jiang
Richard S. Blumberg
Research21 Oct 2019
Nature Immunology

Volume: 20, P: 1644-1655
T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Interrogation of electronic health records and the B and T cell repertoires of people with PSC shows a link between Epstein–Barr virus and primary sclerosing cholangitis, an incurable autoimmune liver disease.

Hesham ElAbd
Mitchell Pesesky
Andre Franke
ResearchOpen Access11 Jun 2025
Nature Medicine

Volume: 31, P: 2306-2316
Efficacy of oral and rectal administration of human faecal microbiota transplant (FMT) in human microbiota-associated mouse models

Petra Hanzely
Kristian Holm
Henrik Rasmussen
ResearchOpen Access22 Dec 2025
Scientific Reports

Volume: 15, P: 1-10
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Tom Karlsen and colleagues report a genome-wide association study for primary sclerosing cholangitis, a chronic bile duct disease. They identify susceptibility loci at MST1 and near BCL2L11.

Espen Melum
Andre Franke
Tom H Karlsen
Research12 Dec 2010
Nature Genetics

Volume: 43, P: 17-19
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

FXR regulates the levels of ACE2 in tissues of the respiratory and gastrointestinal systems that are affected by COVID-19, and inhibiting FXR with ursodeoxycholic acid downregulates ACE2 and reduces susceptibility to SARS-CoV-2 infection.

Teresa Brevini
Mailis Maes
Fotios Sampaziotis
ResearchOpen Access05 Dec 2022
Nature

Volume: 615, P: 134-142
Correction: Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Yu-Hwa Huang
Chen Zhu
Richard S. Blumberg
Amendments and Corrections16 Mar 2016
Nature

Volume: 536, P: 359
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

Repair of defects in the common bile duct is hampered by a lack of healthy donor tissue. Developing human extrahepatic cholangiocyte organoids and testing them in mouse models may provide a way to overcome this limitation.

Fotios Sampaziotis
Alexander W Justin
Ludovic Vallier
Research03 Jul 2017
Nature Medicine

Volume: 23, P: 954-963
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

A protocol for generating biliary epithelial cells from human pluripotent stem cells facilitates disease modeling and drug screening.

Fotios Sampaziotis
Miguel Cardoso de Brito
Ludovic Vallier
Research13 Jul 2015
Nature Biotechnology

Volume: 33, P: 845-852
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants

Trung The Tran
Eline Benno Vaage
Fridtjof Lund-Johansen
ResearchOpen Access30 Dec 2022
npj Vaccines

Volume: 7, P: 1-11
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify four new susceptibility loci for PSC and quantify the correlation of common genetic variation shared between PSC and inflammatory bowel diseases.

Sun-Gou Ji
Brian D Juran
Carl A Anderson
Research19 Dec 2016
Nature Genetics

Volume: 49, P: 269-273
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

CEACAM1 functions as a novel heterophilic ligand for TIM-3 and is necessary for TIM-3-mediated tolerance, which has marked consequences for inflammation, infection and cancer.

Yu-Hwa Huang
Chen Zhu
Richard S. Blumberg
Research26 Oct 2014
Nature

Volume: 517, P: 386-390
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue

Bioengineered biliary tissue suitable for biliary reconstruction is obtained from cholangiocyte organoids derived from human primary extra- or intrahepatic duct cholangiocytes.

Olivia C. Tysoe
Alexander W. Justin
Fotios Sampaziotis
Protocols20 May 2019
Nature Protocols

Volume: 14, P: 1884-1925
Natural killer T cells mediate inflammation in the bile ducts

N. L. Berntsen
B. Fosby
E. Melum
Research16 Aug 2018
Mucosal Immunology

Volume: 11, P: 1582-1590
Scalable production of tissue-like vascularized liver organoids from human PSCs

Sean P. Harrison
Richard Siller
Gareth J. Sullivan
ResearchOpen Access01 Sept 2023
Experimental & Molecular Medicine

Volume: 55, P: 2005-2024
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants

Trung The Tran
Eline Benno Vaage
Fridtjof Lund-Johansen
Amendments and CorrectionsOpen Access25 Jan 2023
npj Vaccines

Volume: 8, P: 1

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