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Reciprocal developmental pathways for the generation of pathogenic effector T_H17 and regulatory T cells

Estelle Bettelli
Yijun Carrier
Vijay K. Kuchroo
Research30 Apr 2006
Nature

Volume: 441, P: 235-238
IL-21 initiates an alternative pathway to induce proinflammatory T_H17 cells

T_H17 cells are a recently defined subset of pro-inflammatory helper T cells that are induced by the cytokines IL-6 and transforming growth factor (TGF)-β. T_H17 can also be induced by an alternative pathway in which TGF-β cooperates with IL-21.

Thomas Korn
Estelle Bettelli
Vijay K. Kuchroo
Research20 Jun 2007
Nature

Volume: 448, P: 484-487
IL-21 and TGF-β are required for differentiation of human T_H17 cells

The T_H17 pathway is thought to contribute to the pathogenesis of a number of human autoimmune diseases. This study examines which cytokines are required for the production of IL-17A by memory and naive human CD4⁺ T cells.

Li Yang
David E. Anderson
David A. Hafler
Research01 Jul 2008
Nature

Volume: 454, P: 350-352
Induction and effector functions of T_H17 cells

Estelle Bettelli
Thomas Korn
Vijay K. Kuchroo
Reviews19 Jun 2008
Nature

Volume: 453, P: 1051-1057
Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4

Simon Glatigny
Rebekka Duhen
Estelle Bettelli
ResearchOpen Access16 Jan 2015
Scientific Reports

Volume: 5, P: 1-7
DOCK8 regulates protective immunity by controlling the function and survival of RORγt⁺ ILCs

Mutations in a scaffolding protein DOCK8 are associated with increased susceptibility to bacterial infections in patients. Here, Singh et al. show that DOCK8 regulates survival and function of a subset of innate lymphoid cells (ILC3) which are involved in the protection against enteric pathogens.

Akhilesh K. Singh
Ahmet Eken
Mohamed Oukka
Research05 Aug 2014
Nature Communications

Volume: 5, P: 1-12
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Thomas Korn
Jayagopala Reddy
Vijay K Kuchroo
Research25 Mar 2007
Nature Medicine

Volume: 13, P: 423-431
Control of T_reg and T_H17 cell differentiation by the aryl hydrocarbon receptor

The aryl hydrocarbon receptor (AHR) is the cellular receptor for a number of environment contaminants. It is shown here to induce regulatory T cells when bound to the ligand TCCD and promote T_H17 differentiation when bound to FICZ.

Francisco J. Quintana
Alexandre S. Basso
Howard L. Weiner
Research23 Mar 2008
Nature

Volume: 453, P: 65-71
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

Amit Awasthi
Yijun Carrier
Howard L Weiner
Research11 Nov 2007
Nature Immunology

Volume: 8, P: 1380-1389
Circulating T_FH cells as a marker for early therapeutic intervention in T1D

Costimulatory blockade via the CTLA-4–Ig fusion protein abatacept is beneficial in patients with early-onset type 1 diabetes, but some individuals benefit more than others. A new study reports that the pretreatment abundance of T follicular helper (T_FH) cells could predict clinical responses to abatacept.

Estelle Bettelli
Daniel J. Campbell
News & Views01 Sept 2020
Nature Immunology

Volume: 21, P: 1141-1142
T_H-17 cells in the circle of immunity and autoimmunity

Estelle Bettelli
Mohamed Oukka
Vijay K Kuchroo
Reviews01 Apr 2007
Nature Immunology

Volume: 8, P: 345-350
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

Kevin C O'Connor
Katherine A McLaughlin
Kai W Wucherpfennig
Research12 Jan 2007
Nature Medicine

Volume: 13, P: 211-217
S1P₁ deletion differentially affects TH17 and Regulatory T cells

Ahmet Eken
Rebekka Duhen
Mohamed Oukka
ResearchOpen Access10 Oct 2017
Scientific Reports

Volume: 7, P: 1-13

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