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Showing 1–2 of 2 results
Advanced filters: Author: Estelle Vincendeau Clear advanced filters

  • MAD2L2 — a member of the shieldin complex — is known to play important roles in DNA repair. Here the authors demonstrate how MAD2L2 dimerization mediated through SHLD2 participates in shieldin assembly and function.

    • Inge de Krijger
    • Bastian Föhr
    • Jacqueline J. L. Jacobs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • SHLD1, as a component of the Shieldin (SHLD) complex, mediates DNA repair via non-homologous end-joining (NHEJ), an essential process during lymphocyte development. Here the authors show that SHLD1 is actually dispensable for lymphocyte development and V(D)J recombination, but is essential for class-switching recombination in activated B cells.

    • Estelle Vincendeau
    • Wenming Wei
    • Ludovic Deriano
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16