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Showing 1–10 of 10 results
Advanced filters: Author: Ethan C. Alley Clear advanced filters

  • Identifying the designers of engineered biological sequences would help promote biotechnological innovation while holding designers accountable. Here the authors present the winners of a 2020 data-science competition which improved on previous attempts to attribute plasmid sequences.

    • Oliver M. Crook
    • Kelsey Lane Warmbrod
    • William J. Bradshaw
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • A deep-learning-guided approach enables protein engineering using only a small number (‘low N’) of functionally characterized variants of target proteins.

    • Surojit Biswas
    • Grigory Khimulya
    • George M. Church
    Research
    Nature Methods
    Volume: 18, P: 389-396

  • A key security challenge with biosecurity threats is determining the responsible actor. In this Perspective, the authors review recent developments in using genetic sequence to assign a lab-of-origin and the potential protection it provides against misuse of synthetic biology.

    • Gregory Lewis
    • Jacob L. Jordan
    • Thomas V. Inglesby
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-4

  • The potential for accidental or deliberate misuse of biotechnology is of concern for international biosecurity. Here the authors apply machine learning to DNA sequences and associated phenotypic data to facilitate genetic engineering attribution and identify country-of-origin and ancestral lab of engineered DNA sequences.

    • Ethan C. Alley
    • Miles Turpin
    • Kevin M. Esvelt
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Contact tracing is critical to controlling COVID-19, but most protocols only “forward-trace” to notify people who were recently exposed. Using a stochastic branching-process model, the authors show that “bidirectional” tracing to identify infector individuals and their other infectees robustly improves outbreak control.

    • William J. Bradshaw
    • Ethan C. Alley
    • Kevin M. Esvelt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • In bacteria, chromosomes are partitioned by the Par system. Super-resolution microscopy demonstrates that ParA and ParB forms a 'spindle-like' structure and suggests that the pole protein, TipN, anchors the DNA-bound ParA filaments at the new pole.

    • Jerod L. Ptacin
    • Steven F. Lee
    • Lucy Shapiro
    Research
    Nature Cell Biology
    Volume: 12, P: 791-798