Early dissemination of cancer cells has been reported to occur in certain breast cancer models. Here the authors show that intra-epithelial macrophages in the early pre-cancer lesions drive early cancer cell dissemination through Wnt-1 secretion and that such events impact the later development of metastasis.
- Nina Linde
- Maria Casanova-Acebes
- Julio A. Aguirre-Ghiso
