Ahmed et al. show that lysine demethylase 8 (Kdm8) maintains the homeostatic cardiac metabolism by repressing Tbx15, thus preventing dilated cardiomyopathy in mice. In humans, KDM8 was downregulated in hearts affected by dilated cardiomyopathy, and higher TBX15 expression correlated with the strongest downregulation of genes encoding mitochondrial proteins.
- Abdalla Ahmed
- Jibran Nehal Syed
- Paul Delgado-Olguín
