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Showing 1–5 of 5 results
Advanced filters: Author: Eugene F. Baulin Clear advanced filters

  • The authors present a statistical and computational framework to identify allele-specific variants, i.e., single nucleotide variants exhibiting allele-specificity (allelic imbalance) in any type of omics assay. Application of this framework to thousands of datasets yields an atlas of chromatin altering variants in diverse cell types.

    • Andrey Buyan
    • Georgy Meshcheryakov
    • Ivan V. Kulakovskiy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Although the Tetrahymena group I intron was the first RNA catalyst discovered, important mechanistic details remain ambiguous. Now six different conformational states of Tetrahymena group I intron self-splicing and an unexpected pseudoknotted structure are resolved by cryogenic electron microscopy.

    • Bingnan Luo
    • Chong Zhang
    • Zhaoming Su
    Research
    Nature Catalysis
    Volume: 6, P: 298-309

  • Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Here the authors present a meta-analysis empowered by a new statistical method covering thousands of ChIP-Seq experiments resulting in the identification of more than 500 thousand allele-specific binding (ASB) events in the human genome.

    • Sergey Abramov
    • Alexandr Boytsov
    • Ivan V. Kulakovskiy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411