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Showing 1–6 of 6 results
Advanced filters: Author: Eugene Kapp Clear advanced filters

  • Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs, priming the RBCs for parasite invasion.

    • Elya Dekel
    • Dana Yaffe
    • Neta Regev-Rudzki
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Crystal structures of BAK core domain dimers suggest a mechanism by which lipids contribute to the oligomerization of BAK, which is essential for BAK-mediated permeabilization of the mitochondrial outer membrane.

    • Angus D. Cowan
    • Nicholas A. Smith
    • Peter E. Czabotar
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 1024-1031

  • To survive and evade host responses, malaria parasites export several hundred proteins into the host cell on infection. A feature of these proteins is a conserved, pentameric motif that is cleaved by an unknown protease before export. This is one of two independent studies revealing the identity of the protease as plasmepsin V, an aspartic acid protease located in the endoplasmic reticulum. This enzyme is essential for parasite viability and is an attractive candidate for drug development.

    • Justin A. Boddey
    • Anthony N. Hodder
    • Alan F. Cowman
    Research
    Nature
    Volume: 463, P: 627-631

  • A multilaboratory analysis characterized the ability of 27 different labs to identify 20 proteins at equimolar concentrations in a highly purified test sample mixture using mass spectrometry. The results show that while the technology is reproducible, many common experimental problems arise, and improved search engines and databases are still needed.

    • Alexander W Bell
    • Eric W Deutsch
    • Juan Antonio Vizcaíno
    Research
    Nature Methods
    Volume: 6, P: 423-430