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Showing 1–4 of 4 results

Advanced filters: Author: Eugene Rudensky Clear advanced filters

Phenotypical and functional specialization of FOXP3⁺ regulatory T cells

This Review describes the recent progress we have made in understanding how regulatory T cell responses are tailored according to the particular nature of the immune environment. The authors discuss the implications for developing new therapies that harness the functions of regulatory T cells.

Daniel J. Campbell
Meghan A. Koch
Reviews25 Jan 2011
Nature Reviews Immunology

Volume: 11, P: 119-130
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death

Intraepithelial lymphocytes expressing γ and δ T cell receptor subunits protect Paneth cells from cell death caused by viral infection or Crohn's disease.

Yu Matsuzawa-Ishimoto
Xiaomin Yao
Ken Cadwell
Research05 Oct 2022
Nature

Volume: 610, P: 547-554
Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota

Autophagy-deficient murine hosts are protected from infection and injury at the intestinal barrier and this is driven by a microbiota-dependent type I interferon response, indicating that autophagy is important for limiting host responses to the microbiota.

Patricia K. Martin
Amanda Marchiando
Ken Cadwell
Research10 Sept 2018
Nature Microbiology

Volume: 3, P: 1131-1141
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57