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Cryo-electron microscopy structures of three large ornate natural bacterial RNA molecules reveal their quaternary structures and intra- and intermolecular interactions that stabilize them.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The hazards of pyroclastic surges remain poorly mitigated globally. Here, the authors show that their destructiveness is amplified by turbulent excursions of dynamic pressure energy that focusses inside the largest eddies and internal gravity waves.

Climate change drives displacement and migration across the Americas, particularly exposing Latin American and Caribbean children to compounded health risks. We explore these health impacts, identify gaps in related US healthcare and health policy, and propose recommendations for how they can respond.

Opacities are considered to be the source of the disagreement between theoretical solar models and helioseismic data. Here, the authors show solar opacity profiles derived from seismic inferences, which differs from theoretical values used in the solar models.

Submarine terraced deposits of some caldera-forming explosive eruptions result from periodic collapses of the eruption column and can be used to estimate their source eruption rate, according to an analysis of such terraces and analogue experiments.

Mass cytometry can be used to scale up multiplexed serology testing, as shown for the simultaneous detection of antibody levels against multiple SARS-CoV-2 proteins in hundreds of serum samples.

Double Asteroid Redirection Test (DART) mission impact on asteroid Dimophos resulted in an elliptical ejecta plume. Here, the authors show that this elliptical ejecta is due to the curvature of the asteroid and makes kinetic momentum transfer less efficient.

A graphical processing unit implementation of an efficient Bayesian-based multiview deconvolution method brings the resolution and contrast advantages of multiview deconvolution to more users of light-sheet fluorescence microscopy.

Double Asteroid Redirection Test (DART) mission’s impact on asteroid Dimorphos has led to various impact related features. Here, the authors show that those features result naturally from the dynamical interaction of the ejecta with the binary system and solar radiation pressure.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

A triangular-lattice Hubbard system realized with ultracold atoms is used to directly image spin polarons, revealing ferromagnetic correlations around a charge dopant, a manifestation of the Nagaoka effect.

Using measurements from 139 global lakes, the authors demonstrate how long-term thermal habitat change in lakes is exacerbated by species’ seasonal and depth-related constraints. They further reveal higher change in tropical lakes, and those with high biodiversity and endemism.

The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Although nanocatalysts forming selective contacts are crucial in photoelectrochemistry, the underlying nanoscale interfaces are poorly understood. Using a n-Si/Ni photoanode and potential-sensing AFM, interfacial electron-transfer processes and photovoltage are measured.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

BRCA1 functions in all cell types to help preserve genomic stability but oncogenesis is restricted to only a few tissues. Here Sedic et al. demonstrate a novel BRCA1haploinsufficiency-induced senescence pathway in epithelial cells.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

Anthracyclines can induce a type 1 interferon response in tumor cells that may predict clinical response to these drugs.

Satellite observations reveal that the Conger–Glenzer Ice Shelf collapse in East Antarctica occurred in four stages spanning a period of 25 years, culminating in its rapid disintegration in March 2022.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Photoelectrochemical water-splitting devices require integrating electrocatalysts with light-absorbing semiconductors, but understanding charge-transfer processes at interfaces has proved difficult. Ion-permeable electrocatalysts deposited onto TiO₂ photoelectrodes now result in adaptive semiconductor/electrocatalyst junctions where both the effective interface barrier height and the photovoltage output change depending on the oxidation state of the electrocatalyst.

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

Experiments and numerical modelling of dilute pyroclastic currents reveal an internal amplification of the dynamic pressure, which suggests that flow-building interactions are stronger when multiphase flow dynamics are accounted for.

Quantum correlations between the laser beams and the positions of the 40-kg mirrors of LIGO are confirmed experimentally, enabling high-precision measurements of both gravitational waves and macroscopic quantum states.

Estrogen has anti-diabetic effects via estrogen receptor alpha (ERα). Here, authors show that via coupled nuclear and non-nuclear actions, ERα in endothelial cells promotes insulin transport to skeletal muscle to foster normal glucose homeostasis.

Loss of Hdac1 and Hdac2 in adult brain is detrimental to neuronal survival and triggers dysregulation of Sapap3 in the striatum in a MeCP2-dependent manner that results in an exacerbated repetitive behavior phenotype.

This report describes a 3D microelectrode array integrated on a thin-film flexible cable using traditional thin-film processing techniques and direct laser writing of 3D structures at micron resolution via two-photon lithography for neural recording.

As phase 1 of the Earth Microbiome Project, analysis of 16S ribosomal RNA sequences from more than 27,000 environmental samples delivers a global picture of the basic structure and drivers of microbial distribution.