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Showing 1–6 of 6 results
Advanced filters: Author: Eva Bednarski Clear advanced filters

  • Zika and Dengue virus non-structural protein 5 can antagonise STAT2 modulating the host response and this interaction is involved in determining tropism. Here the authors show mammals independently evolved resistance to flavivirus NS5 multiple times, involving complex genetic changes in STAT2 which balance viral defence whilst maintaining STAT2’s critical functions.

    • Ethan C. Veit
    • Madihah S. Salim
    • Matthew J. Evans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Here the authors show that SARS-CoV-2 vaccination and boosting, especially in the setting of previous infection, leads to significant increases in antibody levels and neutralizing activity against omicron BA.1 and BA.5 variants in both pregnant patients and their neonates.

    • Elisabeth A. Murphy
    • Camila Guzman-Cardozo
    • Yawei J. Yang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Individual memory antibodies selected over time by natural infection with SARS-CoV-2 have greater potency and breadth than antibodies elicited by vaccination, whereas the overall neutralizing potency of plasma is greater following vaccination.

    • Alice Cho
    • Frauke Muecksch
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 600, P: 517-522

  • A complex range of mutations within the SARS-CoV-2 spike protein is needed to escape polyclonal plasma neutralizing antibodies, and plasma from individuals who were first infected then vaccinated display the greatest resilience to escape mutations.

    • Fabian Schmidt
    • Yiska Weisblum
    • Paul D. Bieniasz
    Research
    Nature
    Volume: 600, P: 512-516