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Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity

How the environment regulates neuronal maturation during brain development is poorly understood. Here, Kreysing et al. identify brain stiffness as a key factor and determine a mechanotransduction pathway linking tissue mechanics to neuronal maturation.

Eva Kreysing
Hélène O. B. Gautier
Kristian Franze
ResearchOpen Access07 Nov 2025
Nature Communications

Volume: 16, P: 1-16

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