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Showing 1–3 of 3 results
Advanced filters: Author: Eva P. Karasmanis Clear advanced filters

  • Using cryo-EM, Karasmanis, Reimer, and Kendrick et al. reveal a Lis1-mediated dynein dimer, termed Chi, that serves as intermediate state in relieving dynein’s autoinhibition.

    • Eva P. Karasmanis
    • Janice M. Reimer
    • Andres E. Leschziner
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1357-1364

  • The molecular motor dynein is modulated by several protein regulators, including LIS1. Here, authors use cryo-EM to show how LIS1 activates dynein by disrupting its autoinhibition and stabilizing intermediate states required to assemble the complexes that mediate transport.

    • Kendrick H. V. Nguyen
    • Eva P. Karasmanis
    • Andres E. Leschziner
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Using cryo-EM, Kendrick et al. reveal multiple dynein conformations during dynein’s mechanochemical cycle and Lis1 binding that represent intermediate states of dynein’s activation.

    • Agnieszka A. Kendrick
    • Kendrick H. V. Nguyen
    • Andres E. Leschziner
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1434-1444