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Showing 1–9 of 9 results
Advanced filters: Author: Evan Heller Clear advanced filters

  • In neurons the membrane-associated periodic skeleton (MPS) consists of actin, spectrin, and associated molecules. Here the authors use proteomic analysis and super-resolution imaging to provide insight into the molecular composition and organization of the MPS, and its functions in axon-diameter regulation and neurite-neurite interactions.

    • Ruobo Zhou
    • Boran Han
    • Xiaowei Zhuang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Here, the first genome-wide in vivo RNA interference screens in a mammalian animal model are reported: genes involved in normal and abnormal epithelial cell growth are studied in developing skin tissue in mouse embryos, and among the findings, β-catenin is shown to act as an antagonist to normal epithelial cell growth as well as promoting oncogene-driven growth.

    • Slobodan Beronja
    • Peter Janki
    • Elaine Fuchs
    Research
    Nature
    Volume: 501, P: 185-190

  • Planar cell polarity (PCP) directs the orientation of mammalian epithelial cells in the skin but it is unclear how polarity is preserved during division. A dileucine motif in the atypical cadherin Celsr1 is shown to trigger the endocytosis of PCP components in mitosis to ensure that they are distributed equally to daughter cells and recycled back to the plasma membrane after division.

    • Danelle Devenport
    • Daniel Oristian
    • Elaine Fuchs
    Research
    Nature Cell Biology
    Volume: 13, P: 893-902

  • Thomas Sander and colleagues identify 15q13.3 microdeletions in 1% of individuals with idiopathic generalized epilepsy (IGE). The majority of these individuals do not show intellectual disability, schizophrenia or other neuropsychiatric phenotypes, thus extending the phenotypic spectrum associated with 15q13.3 microdeletions.

    • Ingo Helbig
    • Heather C Mefford
    • Thomas Sander
    Research
    Nature Genetics
    Volume: 41, P: 160-162

  • In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.

    • Jesse Fajnzylber
    • James Regan
    • Alex Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Mayfield et al. describe the implementation and feasibility of an exclusively remote randomized clinical trial of hydroxychloroquine and azithromycin for the treatment of COVID-19. The trial included monitoring of cardiovascular safety which was successfully done using digital technologies.

    • Jacob J. Mayfield
    • Neal A. Chatterjee
    • Arun R. Sridhar
    ResearchOpen Access
    Communications Medicine
    Volume: 1, P: 1-10