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Showing 1–22 of 22 results
Advanced filters: Author: Evan S. Nair Clear advanced filters

  • The development of subunit vaccines mimicking the molecular complexity of attenuated vaccines has been limited by the difficulty in co-delivery of multiple chemically diverse payloads. Here, the authors report hierarchical hydrogels, assembled from a single homopolymer via a multi-stage process, that enable ratiometric loading of a protein antigen and four physicochemically distinct adjuvants.

    • Fanfan Du
    • Simseok A. Yuk
    • Evan A. Scott
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Peptidoglycan fragments derived from gut bacteria modulate aspects of the host’s health. Here, Li et al. profile peptidoglycan fragments in the host gut and show that one of them, the disaccharide GlcNAc-MurNAc, acts as a mild TLR4 agonist and protects against gut inflammation.

    • Chenyu Li
    • Christopher Adamson
    • Yuan Qiao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

    • Kathie Y. Sun
    • Xiaodong Bai
    • Suganthi Balasubramanian
    ResearchOpen Access
    Nature
    Volume: 631, P: 583-592

  • The authors identify a molecular switch that regulates the balance between neurotoxic and neuroprotective astrocyte populations, with potential application in the treatment of glaucoma and other optic neuropathies.

    • Evan G. Cameron
    • Michael Nahmou
    • Jeffrey L. Goldberg
    Research
    Nature
    Volume: 626, P: 574-582

  • Increased susceptibility to gastrointestinal infections and colitis can be driven by a failure to maintain intestinal homeostasis. Here, using a forward genetic screen, Song et al. identify and characterise the role of TVP23B in Paneth cell and goblet cell function, and its impact on colitis.

    • Ran Song
    • William McAlpine
    • Emre E. Turer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

    • David Amar
    • Nicole R. Gay
    • Elena Volpi
    ResearchOpen Access
    Nature
    Volume: 629, P: 174-183

  • Noninvasively monitoring immune function by positron emission tomography could affect the diagnosis and treatment evaluation of immunological disorders. Progress, however, has been hampered by the lack of probes with distinct biodistribution patterns. Radu et al. exploit the fact that many immune cells utilize a salvage pathway for nucleotide generation during DNA synthesis to develop [18F]FAC (1-(2′-deoxy-2′[18F]fluoroarabinofuranosyl) cytosine), a new probe with increased accumulation in proliferating T cells. Studies in mice show it has advantages over commonly used probes and may be clinically useful.

    • Caius G Radu
    • Chengyi J Shu
    • Owen N Witte
    Research
    Nature Medicine
    Volume: 14, P: 783-788

  • Beutler and colleagues identify skywarp (swp) mice, which exhibit a hypomorphic variant of the U5 splicing protein SNRNP40 and aberrant mRNA splicing specifically in lymphocytes and hematopoietic stem and progenitor cells, suggesting alternative splicing influencing immune cell function.

    • Duanwu Zhang
    • Tao Yue
    • Bruce Beutler
    Research
    Nature Immunology
    Volume: 20, P: 1322-1334

  • The impact of the DART spacecraft on the asteroid Dimorphos is reported and reconstructed, demonstrating that kinetic impactor technology is a viable technique to potentially defend Earth from asteroids.

    • R. Terik Daly
    • Carolyn M. Ernst
    • Yun Zhang
    ResearchOpen Access
    Nature
    Volume: 616, P: 443-447

  • It is known that exercise influences many human traits, but not which tissues and genes are most important. This study connects transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium with human data to identify traits with similar tissue specific gene expression signatures to exercise.

    • Nikolai G. Vetr
    • Nicole R. Gay
    • Stephen B. Montgomery
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The relationship between the components of repetitive head impacts and chronic traumatic encephalopathy (CTE) remains unclear. Here, the authors use American football helmet sensor data to show that duration of play, cumulative head impacts and linear and rotational accelerations are significantly associated with CTE pathology.

    • Daniel H. Daneshvar
    • Evan S. Nair
    • Jesse Mez
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

    • Christopher Abbosh
    • Alexander M. Frankell
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 553-562

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

    • Julie Gonneaud
    • Alex T. Baria
    • Etienne Vachon-Presseau
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57

  • Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.

    • Kavita Praveen
    • Gaurang C. Patel
    • Giovanni Coppola
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15