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Showing 1–28 of 28 results
Advanced filters: Author: Eve Marder Clear advanced filters

  • Small-molecule–neuropeptide co-transmission is pervasive throughout the nervous system of all animals. In this Review, Nusbaum, Blitz and Marder discuss how co-transmission is an important source for the considerable flexibility that has been established for synapses, circuits and behaviour.

    • Michael P. Nusbaum
    • Dawn M. Blitz
    • Eve Marder
    Reviews
    Nature Reviews Neuroscience
    Volume: 18, P: 389-403

  • Membrane excitability is central to neuronal function, and neurons must be resilient to changes in its underlying parameters. In this Perspective article, Marom and Marder suggest that two complementary mechanisms contribute to the resilience of membrane excitability: rapid ‘kinetic-based’ regulation of ion channel proteins and slower homeostatic control of ion channel membrane densities.

    • Shimon Marom
    • Eve Marder
    Reviews
    Nature Reviews Neuroscience
    Volume: 24, P: 640-652

  • Many neuronal and network behaviours are surprisingly stable in the face of ongoing fluctuations in channels and receptors. The authors discuss issues relevant to the homeostatic regulation of synaptic and intrinsic currents necessary for stable neuronal and network activity.

    • Eve Marder
    • Jean-Marc Goaillard
    Reviews
    Nature Reviews Neuroscience
    Volume: 7, P: 563-574

  • The authors found considerable preparation-to-preparation variability in the strength of two identified synapses, the amplitude of a modulator-evoked current and the expression of six ion channel genes in the pyloric circuit of the crab stomatogastric ganglion. These parameters correlated with circuit performance. Circuits produced similar outputs because of compensatory and coordinated changes among the parameters.

    • Jean-Marc Goaillard
    • Adam L Taylor
    • Eve Marder
    Research
    Nature Neuroscience
    Volume: 12, P: 1424-1430

  • Rather than merely firing in a digital on–off fashion, vertebrate neurons may have an analogue aspect to their signalling too — a finding that will not surprise many who have worked on invertebrate neurons.

    • Eve Marder
    News & Views
    Nature
    Volume: 441, P: 702-703

  • A new study in this issue demonstrates that two GABAergic motor neurons in C. elegans are excitatory at target muscles because GABA activates a ligand-gated cation conductance, which is structurally similar to several other ligand-gated channels.

    • Jean-Marc Goaillard
    • Eve Marder
    News & Views
    Nature Neuroscience
    Volume: 6, P: 1121-1122

  • Rhythmic movements such as locomotion are produced by oscillatory circuits in the central nervous system. Work in fruitflies shows that the neural circuitry for such movements develops without peripheral sensory feedback.

    • Eve Marder
    News & Views
    Nature
    Volume: 416, P: 131-132

  • Experimental work suggests that synaptic and intrinsic neuronal properties vary considerably across identified neurons in different animals. The authors propose that instead of building a single model that captures the average behavior of a neuron or circuit, one could construct a population of models with different underlying structure and similar behaviors, as a way of investigating compensatory mechanisms that contribute to neuron and network function.

    • Eve Marder
    • Adam L Taylor
    Reviews
    Nature Neuroscience
    Volume: 14, P: 133-138

  • Citation count has become one of the most important methods to evaluate a scientist’s contributions. In an extensive analysis of citations from a number of leading neuroscience journals, Dworkin and colleagues find evidence of gender bias in citation practices that can have an adverse impact on women’s careers.

    • Adrienne L. Fairhall
    • Eve Marder
    News & Views
    Nature Neuroscience
    Volume: 23, P: 904-905

  • A new paper shows that excitatory and inhibitory neuromodulators can change the firing properties of spinal cord neurons, with implications for pain processing.

    • Eve Marder
    News & Views
    Nature Neuroscience
    Volume: 6, P: 210-212

    • Eve Marder
    Comments & Opinion
    Nature
    Volume: 410, P: 755

  • Evidence suggests that anthropogenic climate change is accelerating, with serious consequences for human health. This Perspective explores how the effects of climate change, such as extreme temperatures, altered weather patterns and increased air pollution, interact with the brain, and discusses how neurologists can respond constructively to the climate crisis.

    • Medine I. Gulcebi
    • Sara Leddy
    • Sanjay M. Sisodiya
    Reviews
    Nature Reviews Neurology
    Volume: 21, P: 216-228

  • In this Historical Perspective, we ask what information is needed beyond connectivity diagrams to understand the function of nervous systems. Informed by invertebrate circuits whose connectivities are known, we highlight the importance of neuronal dynamics and neuromodulation, and the existence of parallel circuits. The vertebrate retina has these features in common with invertebrate circuits, suggesting that they are general across animals. Comparisons across these systems suggest approaches to study the functional organization of large circuits based on existing knowledge of small circuits.

    • Cornelia I Bargmann
    • Eve Marder
    Reviews
    Nature Methods
    Volume: 10, P: 483-490