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Showing 1–14 of 14 results
Advanced filters: Author: Everett E. Vokes Clear advanced filters

  • In the first review of this two-part series, Seiwert and co-authors described the rationale for the use of concurrent chemoradiotherapy for treating malignancies. Here the chemoradiotherapy platforms used for the treatment of head and neck cancer are described and the integration of novel agents such as EGFR inhibitors and antiangiogenic drugs into treatment platforms alongside multiagent-based regimens are reviewed. The authors provide guidance for clinicians based on current clinical trial evidence and suggestions for choosing the most appropriate treatment platform.

    • Tanguy Y Seiwert
    • Joseph K Salama
    • Everett E Vokes
    Reviews
    Nature Clinical Practice Oncology
    Volume: 4, P: 156-171

  • Outcomes for patients with oropharyngeal cancer are determined by their tumor characteristics and associated demographics. The role of human papilloma virus-related disease for prognosis and outcomes with chemoradiotherapy is being more clearly defined. EGFR inhibitors are used in conjunction with radiotherapy, and the importance of optimizing radiation quality and minimizing toxicity is the focus of ongoing studies.

    • Bruce E. Brockstein
    • Everett E. Vokes
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 8, P: 72-74

  • Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosuppressive state.

    • András Piffkó
    • Kaiting Yang
    • Ralph R. Weichselbaum
    Research
    Nature
    Volume: 643, P: 810-819

  • Concurrent chemoradiotherapy is a highly efficacious locoregional treatment option for solid tumors. The rationale for the use of concurrent chemoradiotherapy for treating malignancies, and the molecular basis for combining classic cytotoxic agents and novel targeted therapies agents with radiotherapy are discussed. This article is part one of two articles. In the subsequent article, the general principles outlined here will be applied to head and neck cancer, where the impact of concurrent chemoradiotherapy is particularly evident.

    • Tanguy Y Seiwert
    • Joseph K Salama
    • Everett E Vokes
    Reviews
    Nature Clinical Practice Oncology
    Volume: 4, P: 86-100

  • The IAEA-ACC study compared accelerated radiotherapy with standard radiotherapy in a multicenter trial conducted in developing countries. Advantages were most notable in patients with early-stage disease, which may limit the utility of this therapy. In countries where resources are limited, however, this strategy may be a cost-effective approach to improving outcomes in patients with head and neck cancer.

    • Bruce Brockstein
    • Everett E. Vokes
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 7, P: 616-618

  • Safe clinical deployment of deep learning models for digital pathology requires reliable estimates of predictive uncertainty. Here the authors describe an algorithm for quantifying whole-slide image uncertainty, demonstrating their approach with models trained to distinguish lung cancer subtypes.

    • James M. Dolezal
    • Andrew Srisuwananukorn
    • Alexander T. Pearson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The use of traditional Euclidean geometry can present challenges for analysis of image characteristics, particular those of extremely complex biological structures, obtained by medical and scientific imaging modalities. Fractal geometry is a potentially complementary mathematical approach that enables efficient estimation of geometrical complexity, and the irregularity of shapes and patterns. This Review introduces the concept of fractals and fractal geometry, and describes how analysis of fractal (non-integer) dimension and associated measurements, such as lacunarity (texture), can be performed and applied to the analysis of cancer. The authors discuss how fractal analysis might provide information on many diverse biological structures relevant to the natural history of lung cancer, which might prove useful for the diagnosis and management of this disease.

    • Frances E. Lennon
    • Gianguido C. Cianci
    • Ravi Salgia
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 12, P: 664-675