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Showing 1–18 of 18 results
Advanced filters: Author: Evren U. Azeloglu Clear advanced filters

  • Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated predictive signature of cardiotoxicity.

    • J. G. Coen van Hasselt
    • Rayees Rahman
    • Ravi Iyengar
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.

    • Rhodora C. Calizo
    • Smiti Bhattacharya
    • Evren U. Azeloglu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Using a new computational pipeline for identification of drug-selective transcriptomic responses and FAERS data, the authors identified potential pathways and genomic variants indicative of cancer drug cardiotoxicity in iPSC-derived cardiomyocytes.

    • Jens Hansen
    • Yuguang Xiong
    • Ravi Iyengar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent manner.

    • Amit Ron
    • Evren U. Azeloglu
    • Ravi Iyengar
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • The drug development pipeline for kidney diseases is plagued with challenges ranging from an insufficient understanding of disease mechanisms to a lack of robust preclinical models. Bioengineering approaches have the potential to streamline preclinical drug discovery efforts and improve the success of clinical trials for kidney disease.

    • Nanditha Anandakrishnan
    • Evren U. Azeloglu
    Comments & Opinion
    Nature Reviews Nephrology
    Volume: 16, P: 623-624

  • Biomechanical mechanisms orchestrating stem cell dynamics in development remain unclear. Here the authors show that guidance receptor Plexin-B2 organizes actomyosin contractility, cytoskeletal tension and adhesion during multicellular development of human embryonic stem cells and neuroprogenitor cells.

    • Chrystian Junqueira Alves
    • Rafael Dariolli
    • Roland H. Friedel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-23

  • Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.

    • Chiara Mariottini
    • Leonardo Munari
    • Ravi Iyengar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects of ATG in mouse models of DKD.

    • Yifei Zhong
    • Kyung Lee
    • Ruijie Liu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The authors previously reported HCK was associated with kidney inflammation and fibrosis. Here, they further unravel a mechanism of HCK regulating autophagy within macrophages, altering their polarization, proliferation, and migration and they also developed a more selective HCK inhibitor.

    • Man Chen
    • Madhav C. Menon
    • Chengguo Wei
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • In this Review, the authors examine the biophysical and biomechanical properties that influence podocyte physiology as they integrate and adapt to stimuli from their dynamic environment within the glomerular capillaries. The authors also discuss how dysregulation and loss of biomechanical resilience in podocytes can contribute to kidney disease.

    • Jonathan Haydak
    • Evren U. Azeloglu
    Reviews
    Nature Reviews Nephrology
    Volume: 20, P: 371-385

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • Rajasree Menon
    • Sanjay Jain
    ResearchOpen Access
    Nature
    Volume: 619, P: 585-594

  • Paranjpe, Jayaraman et al. profile the plasma proteome to identify markers of acute and long-term COVID-19-associated kidney dysfunction. They find that while both acute and long-term kidney dysfunction are associated with tubular dysfunction markers, the acute phase is also associated with markers of myocardial damage and hemodynamic disturbance.

    • Ishan Paranjpe
    • Pushkala Jayaraman
    • Girish N. Nadkarni
    ResearchOpen Access
    Communications Medicine
    Volume: 3, P: 1-10