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Showing 1–6 of 6 results
Advanced filters: Author: Ewa M. Roos Clear advanced filters

  • Osteoarthritis (OA) is a chronic condition that is associated with pain and disability. In this Review, Roos and Arden consider the strategies that are available for modification of risk factors contributing to the development of knee OA. Interventions for prevention and early care of knee OA could help to avoid joint-replacement surgery.

    • Ewa M. Roos
    • Nigel K. Arden
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 92-101

  • Research into the effects of lower-extremity muscle weakness on osteoarthritis onset and progression has increased over the past decade, owing to its potential for modification using exercise training interventions. Similarly, afferent sensory dysfunction has also been suggested as an important yet modifiable risk factor for OA progression. In this Review, the authors provide an overview of these risk factors, and discuss the effectiveness of preventive or therapeutic neuromuscular and exercise training interventions.

    • Ewa M. Roos
    • Walter Herzog
    • Kim L. Bennell
    Reviews
    Nature Reviews Rheumatology
    Volume: 7, P: 57-63

  • No drugs are currently approved that change the natural course of osteoarthritis (OA) and translate to long-term, clinically relevant benefits. Two-stage clinical trial designs for OA have now received FDA approval, but remaining challenges lie in defining suitable study populations, surrogate outcomes and pivotal long-term, clinically relevant trial endpoints.

    • L. Stefan Lohmander
    • Ewa M. Roos
    News & Views
    Nature Reviews Rheumatology
    Volume: 15, P: 133-135

  • Establishing suitable outcome measures is an important goal for the classification and monitoring of patients with early knee osteoarthritis. This Perspectives article highlights various outcome measures that have potential use in clinical and/or research settings for early knee osteoarthritis.

    • Carolyn A. Emery
    • Jackie L. Whittaker
    • Nigel K. Arden
    Reviews
    Nature Reviews Rheumatology
    Volume: 15, P: 438-448