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Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Genetic variation in the IFNλ locus has been associated with clearance of hepatitis C virus. Here, the authors show that a single amino-acid variant of IFNλ4 affects its antiviral activity and that patients carrying the impaired variant have better viral clearance rates.

Ewa Terczyńska-Dyla
Stephanie Bibert
Rune Hartmann
Research23 Dec 2014
Nature Communications

Volume: 5, P: 1-9
Correction: Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Ewa Terczyńska-Dyla
Stephanie Bibert
Rune Hartmann
Amendments and Corrections29 Jun 2015
Nature Communications

Volume: 6, P: 1
Antigen presentation by B cells enables epitope spreading across an MHC barrier

Increasing evidence suggests that antigen presentation by B cells is critical to the initiation of autoimmunity. Here, the authors demonstrate that tolerance breakdown is initiated outside of germinal centres and that B cells can directly instruct T cells to break tolerance and propagate autoimmune responses.

Cecilia Fahlquist-Hagert
Thomas R. Wittenborn
Søren E. Degn
ResearchOpen Access31 Oct 2023
Nature Communications

Volume: 14, P: 1-21
Guarding the frontiers: the biology of type III interferons

Type I and III interferons share similar antiviral properties, but there are some important distinctions. Hartmann and colleagues review the specialized functions of type III interferons, including their ability to mediate antiviral functions at barrier surfaces.

Andreas Wack
Ewa Terczyńska-Dyla
Rune Hartmann
Reviews21 Jul 2015
Nature Immunology

Volume: 16, P: 802-809
Frequently used bioinformatics tools overestimate the damaging effect of allelic variants

Line Lykke Andersen
Ewa Terczyńska-Dyla
Rune Hartmann
Research04 Dec 2017
Genes & Immunity

Volume: 20, P: 10-22

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Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Correction: Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Antigen presentation by B cells enables epitope spreading across an MHC barrier

Guarding the frontiers: the biology of type III interferons

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants

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