Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient tumour suppressor genes identifies RPS14, which regulates ribosomal RNA processing as a candidate tumour suppressor gene responsible for this so-called 5q− syndrome.
- Benjamin L. Ebert
- Jennifer Pretz
- Todd R. Golub
