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Showing 1–10 of 10 results
Advanced filters: Author: Fátima Gebauer Clear advanced filters

  • The process that balances expression of X-chromosomal genes between males and females is under tight regulatory control. Here, Militti et al. show that in Drosophila, the RNA-binding protein UNR functions during dosage compensation to promote the interaction between the RNA helicase MLE and the long non-coding RNA roX2.

    • Cristina Militti
    • Sylvain Maenner
    • Fátima Gebauer
    Research
    Nature Communications
    Volume: 5, P: 1-7

  • The role of RNA in preserving the integrity and dynamics of membrane-bound organelles remains largely unexplored. A study now identifies the Golgi-resident protein GM130 as an RNA-binding protein that scaffolds the Golgi ribbon in a polyadenylated-RNA-dependent manner.

    • Fátima Gebauer
    News & Views
    Nature Cell Biology
    Volume: 26, P: 1021-1022

  • RNA-binding proteins (RBPs) are critical effectors of gene expression, and their malfunction underlies many diseases. The authors review the role of RBPs in human genetic disorders, both Mendelian and somatic, discuss the molecular mechanisms of disease and highlight emerging therapeutic interventions that target RBPs.

    • Fátima Gebauer
    • Thomas Schwarzl
    • Matthias W. Hentze
    Reviews
    Nature Reviews Genetics
    Volume: 22, P: 185-198

  • Unlike transcriptional regulation of hESC identity, little is known post-transcriptionally. Here, the authors show that the RNA binding protein CSDE1 regulates core components of hESC identity, neurectoderm commitment and neurogenesis to maintain pluripotency and prevent neural differentiation.

    • Hyun Ju Lee
    • Deniz Bartsch
    • David Vilchez
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • The crystal structure of the RNA binding domains of Sxl and Unr with msl2 RNA shows that interwoven interactions establish cooperative assembly of the ternary complex, highlighting how binding of relatively general RNA binding domains to RNA can result in a unique and specific protein–RNA architecture.

    • Janosch Hennig
    • Cristina Militti
    • Michael Sattler
    Research
    Nature
    Volume: 515, P: 287-290

  • Cap-dependent translation is initiated by the binding of eIF4E to the cap structure at the 5′ end of mRNAs. During hypoxic stress, global translation decreases because eIF4E is inactivated. In a recent article in Nature, Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E, which binds to target mRNAs in complex with a hypoxia-induced RNP.

    • Fátima Gebauer
    Research Highlights
    Cell Research
    Volume: 22, P: 1634-1636